Anti-obesity effects of isoacteoside on 3T3-L1 adipocytes
نویسندگان
چکیده
Abstract Isoacteoside is a caffeoyl phenylethanoide glycoside found in various plant parts, such as the flower of Magnolia denudata . In particular, magnolia has been studied for its anti-obesity, anticancer, and anti-inflammatory effects. However, isoacteoside not extensively studied, except this study, anti-obesity effects were investigated 3T3-L1 mouse pre-adipocytes. treatment did induce cytotoxicity cells up to concentration 1000 μM. The on confirmed using oil red O staining. addition, expression obesity-related proteins genes, peroxisome proliferator-activated acceptor gamma ( PPARγ ), CCAAT/enhancer-binding protein alpha C/EBPα perilipin PLIN1 was determined by western blotting qRT-PCR assays confirm isoacteoside. results study suggest that isoacteoside, natural substance isolated from extracts, highly toxic normal cells, pre-adipocytes, displays vitro.
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ژورنال
عنوان ژورنال: Applied Biological Chemistry
سال: 2022
ISSN: ['2468-0834', '2468-0842']
DOI: https://doi.org/10.1186/s13765-022-00701-1